There is a significant burden of disease associated with limb loss and limb preservation. Nonetheless, there is a paucity of evidence on effective practices and technologies for helping this population. National level data from the multiple stakeholder perspective has been lacking until recently. The national Limb Loss and Preservation Registry (LLPR) has been developed to address this knowledge gap. The LLPR is an organized system designed to make critical data on limb loss, limb preservation, and limb difference available to hospitals, clinics and individual providers, patients, manufacturers, payers, scientists, clinical researchers, and policy makers. The overall objective of the LLPR is to collect, standardize, and report patient outcomes data, support evidence-based decision making, enhance health care delivery, and establish and disseminate best practices. The speakers in this session will discuss the impact of the registry on clinical practice and prosthesis design with emphasis on payor and policy implications.